爱德华·格里芬
Joining the Converse community in 2022, Dr. Griffin has returned to his liberal arts roots, cemented by his undergraduate experience at Saint Michael’s College in Colchester, 佛蒙特州. There, he was a Biochemistry major and self-proclaimed “imposter in the Classics department”. He was inducted into the Sigma Xi honors society on account of his undergraduate research on oligopeptide transporters in germinating rice seeds, funded by a grant from the 佛蒙特州 遗传学 Network. After receiving his BS in Biochemistry in 2010, Dr. Griffin became a research technician at Dartmouth Medical School, where he was co-author of four studies investigating the genetic and molecular mechanisms of biofilm formation in Pseudomonas aeruginosa, as well as co-cultures of microbial colonies on human cystic fibrosis epithelial cells.
In 2012, he started his PhD at the University of Alabama in Tuscaloosa. His doctoral work utilized C. elegans as a model of proteotoxicity in neurodegenerative disease, 即, the role of the vesicular protein sorting protein, Vps41, in anterograde and retrograde trafficking defects in Parkinson’s and Alzheimer’s disease. 在此期间, he mentored nearly a dozen undergraduate researchers, some of which earned co-authorship on the debut of a new C. elegans model of the Alzheimer’s risk factor, Apolipoprotein E. In addition to his research publications, he also published several pieces of poetry, one of which may or may not include his seminal doctoral work, which was written largely in dactylic hexameter without the editor’s knowledge.
At the celebratory dinner following his defense, his outside committee member offered him a postdoctoral position in the department of Neurology at UAB. Dr. Griffin was awarded a postdoctoral fellowship grant from the American Parkinson’s Disease Association to examine the role of T cells in a rodent model of Parkinson’s disease and a radiology pilot grant to investigate the utility of preclinical rodent PET-CT imaging of inflammation in Parkinson’s disease. After his postdoctoral fellowship, he was an instructor of Biology at the University of Alabama, teaching introductory and microbiology labs, 进化, and an introductory course on studying and metacognitive techniques.
Dr. Griffin is married with three children and the first person in his family to earn a PhD. Though he grew up in 佛蒙特州, his father is from Oklahoma, 他的母亲来自丹佛, his childhood friend an Italian from New Jersey, and his wife’s family is from Boston, 把他弄得一团糟. 他喜欢远足。, 皮划艇, and poetry; he is a Tolkien enthusiast; and he is usually woodworking in his free time. He wanted to write this in iambic pentameter, but considered he has more pressing matters.
学术 & 研究活动
Dr. Griffin plans to continue his C. elegans work at Converse and employ rodent models of Parkinson’s disease. 他教细胞生物学, 遗传学, 研究方法, 以及入门课程, and has prospects to develop Immunology, 发育生物学, 和神经生物学课程. As a liberal artist with a proclivity to philosophy and ancient literature, he also looks forward to collaborating on interdisciplinary courses that explore science and human experience.
选定的出版物 & 演讲
神经退行性 VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation. 范德韦勒，R.E.乔布林，R.伯恩斯，C.，桑扎，P.， 10布林克，C.法萨诺，A.陈，L.Zwartkruis, F.J.茨瓦肯伯格，S.格里芬，E.F.范德比克，J.维恩达尔，T.丽芙，N.van Ravenswaaij-Arts, C.M.A.， Lemmink, H.H.p.布拉泽，S.塞普尔韦达，C.洛萨诺，A.M.尹，G.圣地亚哥-西姆，T.阿森西奥，C.S.考德威尔，G.A.考德威尔，K.A.华盛顿州奇蒂亚特市.J . Klumperman. “神经退行性 VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation”. EMBO分子医学 e13258 (2021).
ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegant. 格里芬,E.F.Scopel, S.E.Stephen, C.A.霍兹豪尔，A.C.，瓦吉，M.A.塔基，R.A.伯科维茨，L.A.考德威尔，K.A. 考德威尔，G.A.. ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans. Disease Models and Mechanisms, 12(2); (2019).
Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer’s and Parkinson’s disease models of neurodegeneration. 格里芬,E.F.，元，X.考德威尔，K.A.考德威尔，G.A. (2018) “Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer’s and Parkinson’s disease models of neurodegeneration.” 人类分子遗传学 (selected by the Editors as the cover story); 24 August 2018.